How do I use my Portico Pain Cream?

Instructions and Directions for Use 

  • Apply medication according to instructions received from your physician and pharmacist and according to directions on your medication package.  Use creams consistently in the prescribed amounts and frequencies.  Some of the active ingredients must accumulate in the tissue to achieve the desired pain control.  It is important to use this medication as directed to reach needed concentrations at the site of pain.
  • Wash your hands thoroughly with soap and water prior to applying the cream. Put on disposable gloves. Creams should be applied directly to the affected area.  Skin should be clean and dry.  Avoid applying to open sores or broken skin such as surgical incisions, eczema, acne, etc. Rub creams into the skin well, usually for two to three minutes. 
  • Allow cream to dry and absorb into skin for at least 20 minutes.   
  • If applying after showering or bathing, wait at least 30 minutes to ensure that skin has cooled and dried completely.
  • Do NOT apply heating pad to application area.
  • After applying medication, wash hands thoroughly with soap and water to avoid accidental contact with other people or pets.
  • Medication should be stored at room temperature from 70 to 77 degrees Fahrenheit (22 to 25 degrees C) in a tightly closed container. Avoid exposing medication to extreme heat, cold, moisture, and direct sun or bright light. Brief storage between 59 and 86 degrees Fahrenheit is acceptable during travel or other situations.
  • Contact your physician or pharmacist if your pain does not begin to resolve after 4 to 6 weeks of therapy, or if your symptoms worsen. 

Side Effects 

Most commonly reported side effects include skin irritation involving redness, itching, and rash.  Some may experience increased sensitivity to sunlight. 


Before using these medications, consult with your physician and pharmacist to inform them of your complete medical history, allergies to food and medications, and all prescription and over-the-counter medications you are taking.  Inform them of liver problems, heart problems, asthma, or kidney problems.  

If this medication is accidently introduced into your eyes, rinse and flush your eyes immediately with clean, warm water.  Seek medical attention if irritation persists. 

IF YOU ARE PREGNANT OR SUSPECT YOU ARE PREGNANT, consult with your physician before using topical pain creams.  These products should be avoided during the first trimester if possible.  Please consult your physician or pharmacist to assess potential risks and benefits.  If your product contains an anti-inflammatory medication (i.e. diclofenac or ketoprofen), use should be avoided during the third trimester as this can result in fetal cardiovascular malformations. 

IF YOU ARE OR WILL BE BREAST FEEDING while using these medications, consult with your physician, pediatrician, and/or pharmacist about potential risks to your baby. 


Due to limited systemic absorption, true contraindications to topical pain creams are uncommon.   

Tell your physician or pharmacist if you have ever experienced an anaphylactic or allergic reaction to any component of this formulation, aspirin, NSAIDs, or amide type local anesthetics.  Some commercially manufactured topical products recommend consulting with your doctor prior to the medication use if you: 

  • Have undergone CABG (coronary artery bypass graft) surgery within the last 14 days
  • Have a history of or current stomach ulcers or bleeds
  • Are currently taking blood thinners
  • Are currently taking any antiarrthymic drugs
  • Have experienced asthma exacerbations with the use of aspirin or NSAIDs
  • Have heart disease or a history of stroke
  • Have experienced any serious skin adverse events as a result of NSAID use 

If any of these conditions apply to you, consult with your physician or pharmacist prior to use. 


Contact Portico Pharmacy at 855-899-7258 Monday through Friday between 9 am and 7 pm Mountain Time.